Running programs from external HD?

Sorry for my lack of experience, just wondering what issues I have to consider when doing this.

Specifically, due to the need to use a specific sequencer to modify audio, I need to run two programs and associated plugins on a computer that isn’t my own. Is there a way to avoid installing all the software on this secondary computer? Can I just copy registry setting across or similar, and run the programs from my external hard drive?

that should work fine

i use to do something similar with games having 1/2 their files on an external hd and hotlinking the two folders.