What is your all-time favorite comic? It can be a graphic novel, a complete collected series, or even a single issue, but you have to pick one entity and one entity only. Titles like Watchmen and Sandman are the choices that go without saying for most of us, so it might be wise to avoid them and pick something a little more personal.
A quick exercise to help you narrow it down is this: who are your favorite comic authors? Which one of them do you like most? Which of his works do you feel is his best?
Though Grant Morrison and Frank Quitely’s current run on All Star Superman might end up usurping it once it’s complete, I would say that my all-time favorite comic is The Big City, by Will Eisner. I haven’t seen a better use of the unique characteristics of the comics medium as a means of self-expression, and the artwork is too beautiful. It’s all (very) short stories that depict people living in the city and interacting one another. The beauty is in the minimalism and simplicity; Eisner can tell the whole story about a man and woman arguing just by showing their feet through a sewer grating.