^To elaborate on this:
I make the holes in the top panel first, then sandwich the acrylic (2mm) between the finished panel and a piece of scrap wood. Clamp it down, then line up the drill bit with one of your finished holes (***MAKE SURE IT’S OFF!***)
Finally, pull the drill up, turn it on the lowest setting, and gently ease it into the hole. When you hit the acrylic, push it down GENTLY until you hear a faint snap. Pull out, turn off, get rid of the piece of acrylic which is now goddamn stuck in the drill bit, repeat for the rest.
As for art, I found that good card-paper (forgot the density) works very well.